Table 2.

Mean (SEM) absolute concentrations (μmol/g) of glutamate, glutamine and GSH, corrected for GM, WM and CSF content in ACC, DLPFC and PUT.

Region	Metabolite	Patients with early psychosis, n ACC = 14, n PUT = 16, n DLPFC = 14	Healthy controls, n ACC = 18, n PUT = 18, n DLPFC = 16	t value	p value	Cohen’s d effect size
ACC	Glutamate	11.54 (0.27)	12.24 (0.17)	2.30	0.029	0.80
	Glutamine	3.39 (0.16)	3.93 (0.11)	2.90	0.007	1.01
	GSH	1.38 (0.09)	1.29 (0.06)	−0.90	0.377	0.31
DLPFC	Glutamate	8.87 (0.17)	9.00 (0.65)	0.57	0.571	0.21
	Glutamine	2.48 (0.14)	2.80 (0.10)	1.92	0.065	0.69
	GSH	1.30 (0.07)	1.30 (0.06)	−0.05	0.963	0.02
PUT	Glutamate	9.57 (0.24)	9.67 (0.24)	−0.27	0.793	0.09
	Glutamine	3.22 (0.19)	3.01 (0.15)	0.78	0.440	0.01
	GSH	1.25 (0.09)	1.43 (0.72)	1.61	0.117	0.59

n number of datasets included in the final analysis.