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. 2021 Jul 5;12:4110. doi: 10.1038/s41467-021-24466-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Global view of epigenetic features anchored around the TSS (±5 kb). Genes are segregated into chromatin states. The number of genes in each state is indicated. Genes in each state which were devoid of any marks were excluded from the display. Line colors in aggregate plots reflect the state colors as indicated on the side of the heatmap. B Numbers of expressed gene (FPKM > 1; pink) and silenced genes (FPKM ≤ 1; gray) in different states based on transcriptomic measurements in quiescent mouse livers. C Gene expression level, represented by FPKM, in each state. Liver enriched genes are indicated in red, and the numbers of the liver enriched genes in each state are labeled in red. The location of Fbp1, Fbxo48, and Hoxc10/11 are indicated in alignment with data presented in Fig. 1. Liver enriched genes are indicated in red dots. D Significant GO pathways for genes in in S1, S2, and S6 which were designated as expressed and silenced in panel B. The bubble color and size correspond to state and gene number, respectively. The Y-axis displays arbitrary units used to spread the bubbles for ease of visualization.