Fig. 6. Proliferative genes are expressed in subset of regenerating hepatocytes.

A Uniform Manifold Approximation and Projection (UMAP) was used as a dimension reduction tool to visualize the complex connections among 4000 cells profiled from quiescent livers (orange) and 48 h (teal) after PH. B Expression level of the regenerative gene feature which summarizes the expression of all the genes analyzed in Fig. 5e into a single value is plotted across the same UMAP reduction as in A, highlighting only a few cells express these pro-regenerative genes at this timepoint. C Violin plot showing the expression score of the regenerative gene feature in each cell in quiescent livers and 48 h after PH. Welch t-test was performed on expression score between quiescent and 48 h, triple asterisks (***) indicate p-value < 2.2e-16 by two-side t-test.