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. 2021 Jun 21;7:166. doi: 10.1038/s41420-021-00509-w

Fig. 1. Cloperastine inhabit ESCC cell proliferation.

Fig. 1

A Chemical structure of cloperastine. B, C Cytotoxicity of cloperastine on SHEE, KYSE150, and KYSE450 cells. Cells were treated with cloperastine at various concentrations and then measured cell viability at 24 h and 48 h. D, E Effect of cloperastine on ESCC cell growth. Cells were treated with different doses of cloperastine (0, 2.5, 5, 10, 25 µM) and cells number was measured at 0, 24, 48, 72, 96 h. (*p < 0.05, **p < 0.01, ***p < 0.001). F Effect of cloperastine suppresses anchorage-independent growth of ESCC cells. KYSE150 and KYSE450 were treated with various concentration of cloperastine (0, 2.5, 5, 10, 25 μM) and measure at 7 days. (*p < 0.05, **p < 0.01, ***p < 0.001). G Effect of cloperastine suppresses colony formation of ESCC cells. KYSE150 and KYSE450 were treated with various concentration of cloperastine (0, 2.5, 5, 10, 25 μM) and measure at 12 days. (*p < 0.05, **p < 0.01, ***p < 0.001).