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. 2021 Jun 21;7:166. doi: 10.1038/s41420-021-00509-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The heat map represents the differentially expressed protein in KYSE150 cells treated with DMSO or cloperastine for 24 h. B Volcano map shows 89 up-regulated proteins and 65 down-regulated proteins, and the positions of NDUFA1, NDUFS5, and COX6B1 are marked. C WoLF PSORT software analysis of the subcellular structure localization and classification analysis of differentially expressed proteins. D WoLF PSORT software analysis of the subcellular structure localization and classification analysis of down-regulated proteins. E Down-regulated KEGG pathways enrichment. Data were shown as −Log10 (Fisher’s exact test p-value). F Venn diagram shows a set of down-regulated five pathways and lists three down-regulated proteins, and NDUFA1, NDUFS5, and COX6B1 are marked. G Diagram of protein-protein interaction network of down-regulated proteins, and NDUFA1, NDUFS5, and COX6B1 are located. H The average quantitative kinase data is ranked according to its Log2 FC between the cells after DMSO and cloperastine, and shows the positions of NDUFA1, NDUFS5, and COX6B1. I GSEA analysis of the changes in oxidative phosphorylation of the KEGG gene set after DMSO and cloperastine treatment. J GSEA analysis of the changes in oxidative phosphorylation of the GO gene set after DMSO and cloperastine treatment. K Western blotting for NDUFA1, NDUFS5, and COX6B1 in KYSE150 cells after DMSO and cloperastine treatment.