Table 1.
Loci shared between neuroticism and more than one secondary phenotype.
| Phenotype | CHR | LEAD SNP | MinBP | MaxBP |
|---|---|---|---|---|
| BMI, TG, WHR, SBP AND PP | 1 | rs1460940 | 72628347 | 72959392 |
| SBP, DBP, BMI AND PP | 2 | rs736699 | 26911509 | 26932796 |
| SBP AND PP | 2 | rs343968 | 44905806 | 45004016 |
| SBP, BMI AND PP | 2 | rs848286 | 58007905 | 58674393 |
| CAD, BMI AND PP | 2 | rs72932707 | 203639395 | 204196618 |
| HDL AND DBP | 2 | rs6738482 | 61242410 | 61837947 |
| WHR AND DBP | 2 | rs17741344 | 148457576 | 148853296 |
| TC AND LDL | 3 | rs9853387 | 135798730 | 136503896 |
| CAD, BMI, HDL, LDL, TC AND PP | 3 | rs6788993 | 52277445 | 52838402 |
| SBP, BMI AND PP | 3 | rs12637791 | 85403892 | 85784084 |
| TC, DBP AND SBP | 3 | rs1989839 | 50184538 | 50420554 |
| CAD, DBP AND SBP | 4 | rs4691707 | 156420605 | 156443314 |
| SBP AND PP | 4 | rs16854051 | 41879969 | 42161491 |
| BMI, DBP AND SBP | 4 | rs11722027 | 144028173 | 144215346 |
| CAD, T2D AND DBP | 4 | rs17516389 | 118976252 | 119264162 |
| BMI AND PP | 5 | rs4269288 | 122650049 | 122803786 |
| T2D, DBP, SBP AND PP | 6 | rs10948071 | 43260660 | 43397259 |
| WHR, TG, LDL, CRP AND PP | 6 | rs2856674 | 25450026 | 32963948 |
| HDL, CRP, LDL, TC, TG AND SBP | 6 | rs2269426 | 31578772 | 32189481 |
| CAD, WHR, CRP AND SBP | 6 | rs1490384 | 126659043 | 127080700 |
| CAD, HDL, LDL, WHR, BMI, CRP AND DBP | 6 | rs1077393 | 30997692 | 32189481 |
| T2D AND DBP | 6 | rs2396004 | 43262303 | 43364494 |
| CAD, WHR, CRP, T2D AND DBP | 6 | rs6925689 | 126623947 | 127080700 |
| TC AND LDL | 7 | rs6948810 | 21474610 | 21555536 |
| SBP AND PP | 7 | rs17165701 | 12212919 | 12286050 |
| CAD AND SBP | 7 | rs58673065 | 1843200 | 2110850 |
| CAD AND SBP | 7 | rs6460902 | 12200060 | 12285140 |
| DBP, HDL, BMI, LDL AND PP | 8 | rs7813434 | 116464988 | 116632819 |
| CRP, DBP, SBP AND PP | 8 | rs2736313 | 8088230 | 12199830 |
| WHR AND PP | 9 | rs11791636 | 23805555 | 23827667 |
| SBP AND PP | 9 | rs10821154 | 96155812 | 96381916 |
| SBP AND PP | 9 | rs4838254 | 127766897 | 128399285 |
| SBP, CAD, BMI AND PP | 10 | rs11000925 | 75867193 | 76421529 |
| T2D, DBP AND SBP | 10 | rs10906382 | 13479684 | 13611368 |
| CAD, BMI, DBP, SBP AND PP | 10 | rs77335224 | 104487871 | 105059896 |
| BMI, LDL AND TC | 11 | rs866901 | 77909014 | 78135704 |
| HDL OG TG | 11 | rs10832027 | 13354509 | 13370535 |
| SBP, BMI AND PP | 11 | rs3180446 | 45203212 | 45345244 |
| SBP, CAD, BMI, LDL,TC AND PP | 11 | rs2450122 | 77909014 | 78135704 |
| HDL AND SBP | 11 | rs1988724 | 9958403 | 10370675 |
| BMI AND SBP | 11 | rs11038371 | 45258966 | 45345244 |
| BMI, T2D, CRP, TC, TG, HDL, LDL, PP, DBP, AND SBP | 11 | rs7107356 | 47175327 | 49128599 |
| CAD, BMI, LDL, TC AND SBP | 11 | rs990706 | 77909014 | 78271614 |
| SBP AND PP | 12 | rs79601649 | 49737114 | 50160662 |
| HDL OG TC | 14 | rs12588415 | 75120628 | 75378185 |
| TC, SBP AND PP | 14 | rs1866628 | 75057809 | 75113506 |
| HDL,TC AND DBP | 14 | rs8004084 | 75144618 | 75377692 |
| BMI AND PP | 15 | rs4886937 | 78076272 | 78152626 |
| CAD, SBP, DBP AND PP | 15 | rs17514846 | 91412850 | 91429042 |
| BMI AND SBP | 15 | rs7176782 | 69415482 | 69569464 |
| CAD AND SBP | 15 | rs17514846 | 91412850 | 91429042 |
| TC AND LDL | 16 | rs1002252 | 71278016 | 71376751 |
| BMI, TG AND DBP | 16 | rs1549299 | 30916129 | 31155458 |
| TC AND LDL | 17 | rs12309 | 38122708 | 38219005 |
| TC AND LDL | 17 | rs1230065 | 43461460 | 43534322 |
| SBP AND PP | 17 | rs2165846 | 44941366 | 44947821 |
| CAD AND DBP | 17 | rs55938136 | 43798360 | 43798360 |
| CAD, BMI, WHR, HDL | 18 | rs17700144 | 57728947 | 57987859 |
| HDL OG TG | 19 | rs10409835 | 32830261 | 32994338 |
| BMI AND WHR | 19 | rs9636202 | 18449238 | 18474892 |
| Z in NEUR | Nearest gene |
|---|---|
| 4.35461662317 | RPL31P12 |
| 4.18963785615 | KCNK3 |
| −3.89234482431 | CAMKMT |
| 5.45230886725 | FANCL |
| 4.13516480072 | ICA1L |
| 4.45360597614 | USP34 |
| 5.54325499552 | ACVR2A |
| −4.98578731358 | PCCB |
| 4.29741691262 | SMIM4:PBRM1 |
| −5.00576709809 | CADM2 |
| −5.10311943356 | ZMYND10-AS1:ZMYND10 |
| −4.35330561706 | MTND1P22 |
| −5.43567296604 | BEND4 |
| 3.94478982621 | RP11–284M14.1 |
| −4.33016153627 | PRSS12 |
| −4.89325849576 | CEP120 |
| −4.08127148845 | ZNF318 |
| 5.47679437498 | MTCO3P1 |
| 7.85464688518 | TNXB:ATF6B |
| −5.2537909447 | MIR588 |
| −5.66008277462 | BAG6 |
| 3.72892286408 | ZNF318 |
| 4.68322226982 | RNU6–200P |
| 5.17023483889 | SP4 |
| −6.05105534044 | TMEM106B |
| 4.4437848434 | MAD1L1 |
| 5.92306285077 | TMEM106B |
| 4.17514218028 | TRPS1 |
| −5.84975419193 | LINC00529 |
| −4.68062619372 | ELAVL2 |
| 5.23143409848 | FAM120A |
| −4.98786564489 | HSPA5 |
| −4.11173316994 | ADK |
| −4.36400954759 | BEND7 |
| −5.23859919803 | C10orf32-ASMT:AS3MT |
| −4.31225213337 | GAB2 |
| −5.43398246143 | ARNTL |
| −4.74001727338 | SYT13 |
| 4.27353276097 | GAB2 |
| 4.6699316277 | SBF2 |
| 4.02407371564 | SYT13 |
| −7.04747006968 | AGBL2 |
| −4.17713795565 | RP11–452H21.4 |
| 4.76020126525 | SPATS2 |
| 6.86308309352 | YLPM1 |
| 4.64137402432 | LTBP2 |
| −6.54353852104 | YLPM1 |
| 5.66999702405 | LINGO1 |
| −4.43830518151 | FURIN |
| −3.94284707938 | GLCE |
| −4.43830518151 | FURIN |
| −5.2061488614 | HYDIN |
| 4.47612498022 | PRSS36 |
| −4.91571280463 | MED24 |
| −6.04762128386 | ARHGAP27 |
| 4.77322394436 | WNT9B |
| −11.5419461181 | CRHR1:RP11–105N13.4 |
| −5.50787070534 | RPS3AP49 |
| −5.29319139928 | AC007773.2 |
| −3.89258923647 | PGPEP1 |
BP base position, CHR chromosome, NEUR neuroticism, CAD coronary artery disease, BMI body mass index, WHR waist-hip-ration, HDL high density lipoprotein (HDL), LDL low density lipoprotein, TG triglycerides, TC total cholesterol, T2D, CRP c-reactive protein, SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse-pressure, CIGPRDAY cigarettes smoked per day.