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. 2021 Jul 5;11:13804. doi: 10.1038/s41598-021-93231-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of ultraviolet C (UVC) irradiation on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity. (A) Change in 50% tissue culture infective dose (TCID₅₀) of SARS-CoV-2 after UVC irradiation. SARS-CoV-2 (5 mL) with a titer of 5 × 10⁴ TCID₅₀/mL was irradiated with a UVC light tube for 0, 5, 15 or 30 s and then was titrated using the TCID₅₀ assay with Vero E6/TMPRSS2 cells. Assays are in triplicate and values represent the mean ± standard deviation (SD) of three replicates. Significance has been determined using one-way analysis of variance followed by Dunnett’s multiple comparisons test. The asterisk indicates a statistical difference (*p < 0.05; **p < 0.01). (B) Linear regression analysis to examine the correlation between UVC exposure time and SARS-CoV-2 infectivity.