Table 3.
Univariate and multivariate Cox regression analyses of germinal center numbers in cancer-free LNs for iDFS, dDFS, and OS of HR-negative, their TILs subgroups, all TNBC and low TILs TNBC.
| Covariate P | Model P | HR | CI | |
|---|---|---|---|---|
| (A) All HR-negative cases | ||||
| iDFS | ||||
| All cases (n = 161) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.33 | 0.19–0.59 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.110 | <0.001 | 0.58 | 0.30–1.12 |
| <20% sTILs (n = 86) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.002 | 0.36 | 0.19–0.69 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.023 | 0.004 | 0.41 | 0.19–0.89 |
| ≥20% sTILs (n = 75) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.804 | 1.29 | 0.16–10.16 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.949 | 0.034 | 0.93 | 0.11–7.93 |
| dDFS | ||||
| All cases (n = 161) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.26 | 0.14–0.48 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.033 | <0.001 | 0.47 | 0.23–0.94 |
| <20% sTILs (n = 86) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.28 | 0.14–0.56 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.009 | <0.001 | 0.34 | 0.17–0.77 |
| ≥20% sTILs (n = 75) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.986 | 1.02 | 0.13–8.29 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.665 | 0.031 | 0.61 | 0.07–5.64 |
| OS | ||||
| All cases (n = 161) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.28 | 0.14–0.55 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.351 | <0.001 | 0.69 | 0.32–1.50 |
| <20% sTILs (n = 86) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.006 | 0.36 | 0.17–0.75 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.106 | 0.001 | 0.48 | 0.20–1.17 |
| ≥20% sTILs (n = 75) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.652 | 0.59 | 0.07–5.25 |
| Multivariateb - Total GCs number (≤2 v > 2) | -c | -c | -c | -c |
| (B) Triple-negative breast cancers | ||||
| iDFS | ||||
| All cases (n = 99) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.25 | 0.12–0.52 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.017 | <0.001 | 0.37 | 0.16–0.84 |
| <20% sTILs (n = 52) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.25 | 0.11–0.57 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.003 | 0.016 | 0.26 | 0.10–0.64 |
| dDFS | ||||
| All cases (n = 99) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.20 | 0.09–0.44 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.004 | <0.001 | 0.29 | 0.13–0.67 |
| <20% sTILs (n = 52) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | <0.001 | 0.21 | 0.09–0.49 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.001 | 0.004 | 0.21 | 0.08–0.55 |
| OS | ||||
| All cases (n = 99) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.004 | 0.24 | 0.10–0.60 |
| Multivariatea - Total GCs number (≤2 v > 2) | 0.119 | <0.001 | 0.46 | 0.17–1.22 |
| <20% sTILs (n = 52) | ||||
| Univariate - Total GCs number (≤2 v > 2) | / | 0.013 | 0.29 | 0.11–0.76 |
| Multivariateb - Total GCs number (≤2 v > 2) | 0.036 | 0.005 | 0.32 | 0.11–0.93 |
aAdjusted for Age, pTstage, pNstage, LVI, sTILs & TLS
bAdjusted for Age, pTstage, pNstage, LVI & TLS
cGroup size too small/too few events.