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. 2021 Jun 26;7:157. doi: 10.1038/s41420-021-00552-7

Fig. 1. m6A modification promotes cardiac miR-133a enrichment to its targets.

Fig. 1

A Schematic of screening cardiac miRNAs and identifying miR-133a targets with m6A modification. B m6A consensus motif “GGACH” was inversely complement to the seed region of miR-133a, but not to miR-499. C, D Comparison showing the number and enrichment score of miR-133a or miR-499 targets. The data are obtained from the RISCome RNA-sequencing (Ago2) pull-down on ventricular tissues of 8-week-old male FVB/N mice. E Venn diagram showing the overlap of m6A-modified genes and miR-133a target genes. F The difference of the enrichment score of miR-133a target genes with or without m6A modification. G Venn diagram showing the overlap of m6A-modified genes and miR-499 target genes. H Overall enrichment scores of miR-499 target genes with or without m6A modification. P values were calculated by unpaired two-tailed Student’s t test (D, F, and H).