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Experimental design of the study. Untargeted metabolomics was performed on 51 healthcare workers exposed to the same risk of contracting COVID-19. Twenty-four subjects developed COVID-19 in the weeks following the blood collection, while 27 subjects were more protected and did not develop the disease. The abundance of serum small molecules was used to identify the molecules that may protect individuals from SARS-CoV-2 infection or predispose them to developing it.
