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. 2021 Feb 10;28(7):2112–2125. doi: 10.1038/s41418-021-00739-6

Fig. 1. FBXL6 is upregulated in CRC due to copy number amplification.

Fig. 1

a Volcano-plot of the expression of 18 FBXLs in CRCs based on TCGA RNA-Seq data. FBXL6 exhibited significant differential expression (p < 0.001, absolute fold change > 1.5) when comparing CRC tumors with adjacent normal colorectal tissues (T/N). b Relative FBXL6 mRNA levels in CRC tumors and normal colorectal tissues from TCGA, GSE41258, and GSE23878 databases. FBXL6 is upregulated in CRCs. c ROC plot showing the AUC of the FBXL6 expression from TCGA, GSE41258, and GSE23878 databases. d Protein levels of FBXL6 in human CRC samples were determined by western blot. β-actin was used as a loading control. e FBXL6 mRNA levels and CNVs were assessed from the TCGA colorectal tissue (n = 612) and CCLE Affy (n = 59) databases. R, Spearman correlation coefficient. Boxplots show median, quartiles, min, and max. p values of boxplots are based on the Mann–Whitney test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.