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. 2021 Feb 10;28(7):2112–2125. doi: 10.1038/s41418-021-00739-6

Fig. 8. Schematic summary shows that FBXL6 promotes CRC growth by degrading phospho-p53 (S315).

Fig. 8

In CRCs, high-level FBXL6 driven by gene amplification promotes phospho-p53 (S315) degradation. AURKA and CDK16 along with other kinases may mediate p53 (S315) phosphorylation. The loss of p53 helps to promote CRC development and or its survival.