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. 2021 Jul 5;11:13864. doi: 10.1038/s41598-021-93208-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A panel of representative cores with scoring of tumor epithelium and tumor stroma for miR-17-5p stained by ISH. TE is scored by the intensity of the staining in the cell cytoplasm and core, with values from 0–3, and TS is scored by the density of positive cells in the examined core. (a) Score 1 in TE; (b) Score 2 in TE; (c) Score 3 in TE; (d) Score 1 in TS; (e) Score 2 in TS; (f) Score 3 in TS; (g) U6 control staining; (h) Positive tissue control: normal human colon tissue; (i) Negative tissue control: normal human brain tissue. Magnification 20x.