Fig. 3. Neural molecular substrates of lithium determining its differential affinity and efficacy for BD1 vs BD2.

Circles represent neural molecular substrates of Li⁺. Red circles represent the most abundant neural targets of Li⁺ underlying its therapeutic efficacy in mania (BD1); blue and yellow circles indicate a progressively decreasing number of neural molecular substrates of Li⁺ in minor and major depressive disorders (cyclothymia and BD2).