Table 2.

ROC curve analysis of miRNA expression levels in different groups.

	miR-137	miR-34a	miR-34b	miR-34c	miR-137	miR-34a	miR-34b	miR-34c
	SZ vs. HC				EOS vs. HC
AUC	0.885	0.517	0.751	0.699	0.911	0.567	0.862	0.693
Accuracy	0.794	0.533	0.689	0.651	0.828	0.451	0.799	0.583
Sensitivity	0.795	0.684	0.772	0.749	0.856	0.635	0.808	0.587
Specificity	0.790	0.210	0.510	0.440	0.800	0.260	0.790	0.580
	EOS vs. AOS				AOS vs. HC
AUC	0.584	0.596	0.810	0.502	0.861	0.531	0.647	0.705
Accuracy	0.484	0.563	0.786	0.484	0.754	0.521	0.597	0.592
Sensitivity	0.404	0.423	0.740	1.000	0.802	0.991	0.685	0.622
Specificity	0.559	0.694	0.829	0.000	0.700	0.000	0.500	0.560
	ROS vs. HC				REOS vs. HC
AUC	0.884	0.628	0.795	0.776	0.902	0.604	0.967	0.721
Accuracy	0.785	0.535	0.663	0.669	0.708	0.269	0.892	0.652
Sensitivity	0.819	0.722	0.750	0.694	0.833	0.867	0.900	0.633
Specificity	0.760	0.540	0.600	0.650	0.670	0.009	0.890	0.540
	REOS vs. RAOS				RAOS vs. HC
AUC	0.658	0.545	0.922	0.620	0.871	0.645	0.671	0.815
Accuracy	0.667	0.333	0.833	0.625	0.732	0.373	0.542	0.683
Sensitivity	0.810	0.143	0.833	0.714	0.810	0.810	0.762	0.762
Specificity	0.467	0.600	0.833	0.500	0.700	0.019	0.450	0.650
	SZ with NSS vs. HC				EOS with NSS vs. HC
AUC	0.927	0.662	0.742	0.690	0.957	0.598	0.826	0.749
Accuracy	0.832	0.526	0.638	0.571	0.881	0.462	0.783	0.687
Sensitivity	0.865	0.635	0.677	0.615	0.907	0.651	0.791	0.698
Specificity	0.800	0.420	0.600	0.530	0.780	0.380	0.780	0.540
	EOS with NSS vs. AOS with NSS				AOS with NSS vs. HC
AUC	0.604	0.534	0.769	0.583	0.899	0.629	0.637	0.647
Accuracy	0.472	0.404	0.685	0.517	0.795	0.527	0.548	0.486
Sensitivity	0.558	0.535	0.767	0.674	0.826	0.695	0.630	0.630
Specificity	0.391	0.283	0.609	0.370	0.780	0.490	0.510	0.540

AOS adult-onset schizophrenia, EOS early-onset schizophrenia, HC healthy controls, NSS neurological soft signs, RAOS unaffected first-degree relatives of AOS patients, ROS unaffected first-degree relatives of patients with schizophrenia, REOS unaffected first-degree relatives of EOS patients, SZ schizophrenia.