Table 1.
Baseline and demographic characteristics.
| Total (n = 30) | Survivors (n = 23) | Death/LT (n = 7) | P-value | |
|---|---|---|---|---|
| Male sex, n (%) | 20 (67) | 14 (61) | 6 (86) | 0.37 |
| Age (years), median (range) | 55.5 (38–74) | 54 (38–71) | 62 (47–74) | 0.22 |
| LiMAx one day before TIPS [µg/kg/h], median (range) | 233 (77–538) | 249 (77–538) | 178 (90–205) | 0.01 |
| LiMAx one day after TIPS [µg/kg/h], median (range) | 195 (65–345) | 207 (65–345) | 80 (75–214) | < 0.01 |
| LiMAx drop one day after TIPS [µg/kg/h], median (range) | -44.5 (-303–58) | -44 (-303–58) | -46 (-98–34) | 0.86 |
| HVPG pre TIPS [mmHg], median (range) | 22 (14–34) | 23 (15–34) | 22 (14–29) | 0.31 |
| HVPG post TIPS [mmHg], median (range) | 9 (5–12) | 9 (5–12) | 8 (5–12) | 0.44 |
| HVPG drop [mmHg], median (range) | 14 (6–24) | 14 (6–24) | 13 (7–17) | 0.54 |
| TIPS diameter [mm], median (range) | 8 (6–10) | 8 (6–10) | 6 (6–8) | 0.14 |
| MELD score, median (range) | 12 (6–23) | 10 (6–22) | 16 (10–23) | 0.02 |
| Child Pugh score [points], median (range) | 8 (5–11) | 8 (5–11) | 9 (7–11) | 0.05 |
| Child Pugh stage | 0.40 | |||
| Class A, n (%) | 3 (10) | 3 (13) | 0 (0) | |
| Class B, n (%) | 20 (67) | 16 (70) | 4 (57) | |
| Class C, n (%) | 7 (23) | 4 (17) | 3 (43) | |
| Origin of cirrhosis (n, %) | 0.60 | |||
| Alcohol | 22 (73) | 17 (74) | 5 (71) | |
| NASH | 5 (17) | 4 (17) | 1 (14) | |
| HCV | 1 (3) | 0 (0) | 1 (14) | |
| PBC | 1 (3) | 1 (4) | 0 (0) | |
| AIH | 1 (3) | 1 (4) | 0 (0) | |
| Indication of TIPS placement (n, %) | 0.30 | |||
| Ascites | 25 (83) | 18 (78) | 7 (100) | |
| Variceal bleeding | 5 (17) | 5 (22) | 0 (0) | |
| Laboratory parameters (median, SD) | ||||
| Platelets (per nL) | 145 (124.1) | 151 (134.9) | 103 (49.9) | 0.04 |
| Creatinine (mg/dL) | 1.1 (1.3) | 1.1 (1.5) | 1.9 (0.6) | 0.11 |
| Bilirubin (mg/dL) | 1.0 (1.0) | 1.0 (0.9) | 1.8 (1.1) | 0.29 |
| AST (U/L) | 41 (33.7) | 42 (37.8) | 36 (14.8) | 0.35 |
| ALT (U/L) | 21 (20.4) | 21 (23.4) | 21 (6.7) | 0.92 |
| Albumin (g/dL) | 3.2 (0.6) | 3.2 (0.7) | 3.0 (0.4) | 0.59 |
| INR | 1.16 (0.2) | 1.12 (0.2) | 1.34 (0.2) | 0.07 |
Bold values indicate statistically significant at P < 0.05.
AIH autoimmune hepatitis, ALT alanine aminotransferase, AST aspartate aminotransferase, HCV hepatitis C virus, HVPG hepatic venous pressure gradient, INR international normalized ratio, MELD model for end-stage liver disease, NASH non-alcoholic steatohepatitis, PBC primary biliary cholangitis, TIPS transjugular intrahepatic portosystemic shunt.