Table 3.
Analysis of diagnostic accuracy of different parameters in prediction of transplant-free survival after TIPS.
| Sensitivity [%] | Specificity [%] | PPV [%] | NPV [%] | Cut-off | Youden index | AUROC | |
|---|---|---|---|---|---|---|---|
| LiMAx one day before TIPS | 100.0 | 73.9 | 53.9 | 100.0 | ≤ 205 | 0.74 | 0.82 |
| LiMAx one day after TIPS | 85.7 | 78.3 | 54.6 | 94.7 | ≤ 165 | 0.64 | 0.85 |
| Creatinine | 71.4 | 87.0 | 62.5 | 90.9 | ≥ 1.87 | 0.58 | 0.70 |
| Child Pugh points | 85.7 | 65.2 | 42.9 | 93.8 | ≥ 9 | 0.51 | 0.74 |
| MELD score | 71.4 | 73.9 | 45.5 | 89.5 | ≥ 15 | 0.45 | 0.80 |
| INR | 57.1 | 87.0 | 57.1 | 87.0 | ≥ 1.34 | 0.44 | 0.73 |
| Bilirubin | 57.1 | 87.0 | 57.1 | 87.0 | ≥ 1.8 | 0.44 | 0.63 |
| Platelets | 100.0 | 43.5 | 35.0 | 100.0 | ≥ 165 | 0.43 | 0.76 |
| Age | 71.71.43 | 69.6 | 41.7 | 88.9 | ≥ 61 | 0.42 | 0.65 |
| LiMAx drop at day after TIPS | 100.0 | 26.1 | 29.2 | 100.0 | ≥ -98 | 0.26 | 0.49 |
| AST | 42.9 | 82.6 | 42.9 | 82.6 | ≤ 29 | 0.25 | 0.62 |
| Albumin | 85.7 | 39.1 | 30.0 | 90.0 | ≤ 3.4 | 0.25 | 0.57 |
| HVPG before TIPS | 71.4 | 52.2 | 31.3 | 85.7 | ≤ 22 | 0.24 | 0.63 |
| Change in HVPG | 100.0 | 21.7 | 28.0 | 100.0 | ≤ 17 | 0.22 | 0.58 |
| HVPG after TIPS | 42.9 | 78.3 | 37.5 | 81.8 | ≤ 6 | 0.21 | 0.60 |
| ALT | 100.0 | 17.4 | 26.9 | 100.0 | ≤ 33 | 0.17 | 0.49 |
ALT alanine aminotransferase, AST aspartate aminotransferase, AUROC area under receiver operating characteristics, HVPG hepatic venous pressure gradient, INR international normalized ratio, MELD model for end-stage liver disease, NPV negative predictive value, PPV positive predictive value, TIPS transjugular intrahepatic portosystemic shunt.