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. 2021 Jul 5;12:4126. doi: 10.1038/s41467-021-24341-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a BRCA1 and DHX9 are in the same genetic pathway for the repair of an I-Sce1 induced DSB by HR measured in a pDR-GFP assay. Data were from three independent experiments. Statistical significance was established using a one-way ANOVA with post hoc Tukey’s test (****p < 0.0001). b Fluorescence images of BRCA1 (red) and DHX9 (green) co-localize in DNA Damage induced nuclear foci. The graph depicts the Pearson coefficient for co-localization of DHX9 and BRCA1 in untreated cells and cells treated with 1 μM camptothecin for 2 h. Differences in mean values for three independent experiments were shown to be statistically significant using a one-way t-test (****p < 0.0001). Error bars indicating one standard deviation are also indicated. Source data are provided as a Source Data file.