Table 1.

Expression and prognosis values of WWP1 in human cancers.

Cancer type	Expression level of tumor	Clinicopathological features and prognosis values	Reference
Colorectal cancer	Increased	High expression of WWP1 was related with tumor size, T classification, TNM stage, distant metastasis and poor survival	[23]
Osteosarcomas	Upregulated	WWP1 expression was associated with single-nucleotide polymorphisms and copy number variants	[24, 35]
Oral cancer	Upregulated	N/A	[25]
Gastric cancer	Increased	High expression of WWP1 was associated with TNM stage, lymph node metastasis, invasive depth and poor prognosis	[26]
Melanoma	Poor expression	N/A	[27]
Prostate cancer	Upregulated	N/A	[28–30]
Breast cancer	Upregulated	Patients with only nuclear-localized WWP1 in tumors had favorable prognosis. And low/absent WWP1 level indicated the worst prognosis	[31–33]
Hepatocellular cancer	Elevated	WWP1 level was linked to tumor size, histological grade, TNM stage, vascular invasion and tumor capsule, poorer prognosis	[36, 37]
Chronic lymphocytic leukemia	Higher	High expression of WWP1 was related with adverse prognostic factors including CD38 and ZAP-70	[38]
Cutaneous squamous cell carcinoma	Augmented	High expression of WWP1 was associated with histological grade, invasion depth, lymph node metastasis and unfavorable prognosis	[39]