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. 2021 Jun 22;9:660482. doi: 10.3389/fped.2021.660482

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Copyright © 2021 Eloranta, Nousiainen, Cairo, Pakarinen, Wilson, Pihlajoki and Heikinheimo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NRP2 silencing reduces stress fiber formation and actin protrusions in HB cells. Nuclear staining with DAPI in NT (A,I) or NRP2 siRNA (E,M) treated cells. Cells having undisturbed NRP2 expression (B,J) stained with F-actin demonstrated more prominent cellular protrusions (arrow) and cytoplasmic accumulation of stress fibers compared to NRP2 knockdown cells (F,N). Close-up images (C,G,K,O) of (B,J) and (F,N) showing localization of stress fibers (arrowhead). Merged images of DAPI and F-actin staining in NT control cells (D,L) and NRP2 knockdown cells (H,P). Scale bar: 20 μm (A,B,D–F,H–J,L–N,P). NT, non-targeting.