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. 2021 Jun 22;9:660482. doi: 10.3389/fped.2021.660482

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Copyright © 2021 Eloranta, Nousiainen, Cairo, Pakarinen, Wilson, Pihlajoki and Heikinheimo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NRP2 silencing decreases HB cell migration. After 40 h, decreased numbers of NRP2 siRNA treated HUH6 and HB-282 cells migrated through the transwell membrane when compared to cells with an intact NRP2 expression (A,B,D,E); the relative cell migration was 2.2-fold higher in HUH6 and 6.2-fold higher in HB-282 NT control cells compared to NRP2 silenced cells (C,F). Bar plots are presented as relative values of mean of three independent experiments ± RSD. **p-value < 0.01. NT, non-targeting.