Fig. 2.

Scatter plot of Bayley-III average Cognitive/Language score (CLC) at 18m vs MRI Total Injury Score (TIS). The horizontal dotted line indicates a Bayley-III CLC score of 85, comparable to Bayley-II MDI of 70 (30) Eight scanned non-surviving infants were allocated a score of 41. Eleven of the 12 infants cooled following postnatal collapse (PNC) are indicated (10 survivors blue filled circle and 1 non-survivor blue star). The one child with PNC not shown, did not have a Bayley assessment and had TIS of 1 and a favourable outcome. One survivor, later diagnosed with a metabolic disorder, also had PNC. Nine of the 12 cooled infants who had additional diagnoses are indicated; of the 3 infants not shown, 2 died before an MRI could be acquired, 1 with major congenital anomalies and the other with transposition of the great arteries, 1 survivor with microdeletion syndrome 15q11.2 did not have a Bayley-III and had a TIS of 4 and an adverse outcome. Only five infants without PNC or other diagnosis had low Bayley-III CLC scores <85 at 18m despite low TIS scores of 2 and 3. Two had hearing loss at 18m, which improved in one by 24m, but the other had GMFCS Level I CP and went on to require hearing aids, the third developed infantile seizures that were difficult to control, the fourth was later diagnosed with Autistic Spectrum Disorder and no explanation was found for the fifth child. All 147 infants without PNC or additional diagnoses with a TIS of 4 or 5 had a Bayley-III CLC score >85, however one was diagnosed with GMFCS Level I CP at 24m. TIS scores of 6 or 7 were found in 16 infants, of whom 7 had a adverse outcome with one death and 3 with severe hearing loss. Nine had a favourable outcome but included 4 with mild CP, GMFCS Level I. Of the 14 infants with a TIS of 8–11 there were 7 neonatal deaths, 7 with severe CP (GMFCS Level V) and poor cognition and one with GMFCS Level I, dyskinetic CP had Bayley-III CLC score >85.