Fig. 3.

The figure shows the scatter plot of individual Bayley-III Motor Score at 18 months versus the WMxBGT product score for the 168 children. The horizontal dotted line indicated a Bayley-III score of 85. The inset lists details the WM and BGT scores, the product WMxBGT with the corresponding outcomes. Eight scanned non-survivors were allocated a Bayley-III score of 41 (star sign). 21/22 infants diagnosed with cerebral palsy (CP) are indicated according to their Gross Motor Function Classification System (GMFCS) Levels. ^aOne infant, GMFCS Level I CP, did not have a Bayley-III assessment. Seven of the 12 infants with CP GMFCS Level I had Bayley-III average Cognitive/Language (CLC) scores ≥85. The only child with CP GMFCS Level III had Bayley-III C CLC score of 85. The remaining 8 infants with CP GMFCS Levels IV and V had Bayley-III Cognitive/Language scores <55. Eight of nine infants with severe CP (Levels III-V) had a WMxBGT product of 6 or 9. Six of the eight children who died had a product of 9 and two had 4. All but one child with CP GMFCS Levels III-V had WMxBGT 6 or 9; the exception was an infant with WMxBGT 6, later diagnosed with complex-1 respiratory chain enzyme deficiency. When any BGT injury was present, the severity of WM injury appeared to negatively modulate outcome. Infants with WM score 3 and no BGT injury had a favourable outcome; for infants with BGT score 2 or 3, outcome worsened with increasing severity of WM injury.