. 2021 May 17;36:100885. doi: 10.1016/j.eclinm.2021.100885

Table. 1.

Left part shows four blocks of regression results, each with the regression applied to one of 4 sub-group of infants: 1: n = 168 total scanned cohort, 2:n = 158 excluding 10 scanned infants with coexisting diagnosis. 12 PNC are included, 3: n = 156 excluding 12 infants with PNC including 10 with coexisting diagnosis, 4: n = 146 excluding 22 scanned infants with PNC or other diagnosis. In each block, the upper part gives the results from regressions corresponding to the one performed in Supplementary document 1. The upper part of the upper block repeats the results obtained in the second regression in Supplementary document 1. In the lower half of each block, the product WMxBGT is not allowed in the regression, but all other MRI and biochemical and clinical variables are allowed. For each regression, the significant factors in the regression equation are listed with the corresponding factors. The resulting 2 × 2 tables are shown with the Positive Predictive Value (PPV) for adverse outcome, the Negative Predictive Value (NPV) for adverse outcome, Specificity (Sp), Sensitivity (Se) and Predictive Accuracy (PA). Right part shows the description as for the left part, but with classifications from cross tables with only one MRI variable selected, either WMxBGT or TIS, in each block.

	Variables allowed	Steps in binary logistic regression	B value (B₀-B3)	Outcome using binary logistic regression				Cut off variable used	Cut-off for binary outcome prediction	Outcome using cross-tables
	Variables allowed	Steps in binary logistic regression	B value (B₀-B3)	Favourable	Adverse	Total	NPV, PPV & Predictive Accuracy	Cut off variable used	Cut-off for binary outcome prediction	Favourable	Adverse	Total	NPV, PPV & PA
1:n=168 Total scanned [$]\\vskip 50\\bf\\rotate 90{?>cohort (9 dead and one [$]\\vskip 24\\hskip 6\\bf\\rotate 90{?>survivor excluded)	All MRI, clinical and biochemical variables	0:constant	-3.370	129	14	143	90% ^NPV	WMxBGT	≤2	126	13	139	91%^NPV
		1:WMxBGT	0.693	3	22	25	88%^PPV		>2	6	23	29	79%^PPV
		2:LDH72h	0.036	132	36	168				132	36	168
				98% ^Sp	61% ^Se		90%^PA			95% ^Sp	64%^Se		89%^PA

	As above except WMxBGT	0:constant	-4.425	127	14	141	90% ^NPV	Total Injury Score	≤5	123	12	135	91%^NPV
		1:TIS	0.587	5	22	27	81%^PPV		>5	9	24	33	73%^PPV
		2:LDH72h	0.028	132	36	168				132	36	168
			96% ^Sp	67% ^Se		89%^PA			93%^Sp	67%^Se		88% ^PA

2:n=158 Excluding 10 [$]\\vskip 50\\bf\\rotate 90{?>scanned infants with [$]\\vskip 24\\hskip 6\\bf\\rotate 90{?>co-existing diagnoses 12 [$]\\vskip --10\\hskip 13\\bf\\rotate 90{?>(PNC are included)	All MRI, clinical and biochemical variables	0:constant	-4.185	123	11	134	92%^NPV	WMxBGT	≤2	122	10	132	92%^NPV
		1:WMxBGT	0.745	4	20	24	83%^PPV		>2	5	21	26	81%^PPV
		2:timeLact<5	0.049	127	31	158				127	31	158
		3:no inotrope	0.581	97% ^Sp	65%^Se		91% ^PA			96%^Sp	68%^Se		91% ^PA

	As above except WMxBGT	0:constant	-4.968	124	11	135	93%^NPV	Total Injury Score	≤5	118	9	127	93%^NPV
		1:TIS	0.632	3	20	23	87%^PPV		>5	9	22	31	71%^PPV
		2:peakLDH	0.023	127	31	158				127	31	158
			98% ^Sp	65%^Se		91% ^PA			93%^Sp	71%^Se		89% ^{PA c}

3: n=156 Excluding [$]\\vskip 52\\bf\\rotate 90{?>12 infants with PNC and [$]\\hskip 6\\vskip 25\\bf\\rotate 90{?>including 10 with [$]\\hskip 12\\vskip 0\\bf\\rotate 90{?>co-existing diagnoses	All MRI, clinical and biochemical variables	0:constant	-4.191	120	10	130	92%^NPV	WMxBGT	≤2	118	11	129	91%^NPV
		1:WMxBGT	0.695	3	23	26	88%^PPV		>2	5	22	27	81%^PPV
		2:LDH72h	0.036	123	33	156				123	33	156
		3:no inotrope	0.485	98% ^Sp	70% ^Se		92% ^PA			96%^Sp	67%^Se		90% ^{PA c}

	As above except WMxBGT	0:constant	-4.943	119	10	129	92%^NPV	Total Injury Score	≤5	115	10	125	92%^NPV
		1:TIS	0.679	4	23	27	85%^PPV		>5	8	23	31	74%^PPV
		2:peakLDH	0.040	123	33	156				123	33	156
		3:no adren	-0.078
			97% ^Sp	70% ^Se		91% ^PA			93%^Sp	70%^Se		88% ^PA

4: n=146 Excluding [$]\\vskip 51\\bf\\rotate 90{?>22 scanned infants with [$]\\hskip 6\\vskip 25\\bf\\rotate 90{?>PNC and co-existing [$]\\hskip 12\\vskip --1\\bf\\rotate 90{?>diagnoses	All MRI, clinical and biochemical variables	0: constant	-4.640	117	9	126	93%^NPV	WMxBGT	≤2	114	8	122	93%^NPV
		1:WMxBGT	1.082	1	19	20	95%^PPV		>2	4	20	24	83%^PPV
		2:no inotrope	1.077	118	28	146				118	28	146
		3:no adren bolus	-1.905	99% ^Sp	68% ^Se		93% ^PA			97% ^Sp	71% ^Se		92% ^PA

	As above except WMxBGT	0: constant	-5.675	116	10	126	92%^NPV	Total Injury Score	≤5	110	7	117	94%^NPV
		1:TIS	0.772	2	18	20	90%^PPV		>5	8	21	29	72%^PPV
		2:no inotrope	0.756	118	28	146				118	28	146
3:no adren bolus:		-1.113	98% ^Sp	64% ^Se		92% ^PA			93%^Sp	75%^Se		90% ^PA