Table 2.
shows the results from regression analyses of two different subgroups: 1:Predicting severe CP, 2:Predicitng all CP. Each block the upper part shows the results when all MRI variables and all clinical variables are allowed. The middle part, the results when all MRI variables except WMxBGT and clinical variables are allowed, and the lower part, the results when only clinical variables are allowed in the regression.
| Patient cohorts | Dependent variable | Steps in logistic regression | Logistic regression & BIC |
Actual outcome |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| B value | Significance per step | −2ln likely hood | BIC | N | Favourable | Adverse | Total | %NPV,% PPV &%PA | |||
| 1: Predicting severe CP n = 160 excluding 17 dead 1 survivor not scanned - |
n = 9 All MRI, clinical and biochemic. variables |
0:constant | −7.710 | 160 | 148 | 1 | 149 | 99%NPV | |||
| 1:WMxBGT | 1.334 | 0.002 | 14.615 | 29.841 | 3 | 8 | 11 | 73%PPV | |||
| 151 | 9 | 160 | |||||||||
| 98%Sp | 89% Se | 98% PA | |||||||||
|
n = 9 All MRI, except WMxBGT, and clinical and biochemical variables |
0:constant | −10.270 | 160 | 149 | 3 | 152 | 98%NPV | ||||
| 1:TIS | 1.457 | 0.002 | 23.147 | 38.371 | 2 | 6 | 8 | 75%PPV | |||
| 2:startact cool | −0.446 | 0.05 | 18.690 | 38.990 | 151 | 9 | 160 | ||||
| 98% Sp | 67% Se | 97% PA | |||||||||
|
n = 9 Clinical and biochemical variables only |
0:constant | −12.441 | 0.000 | 160 | 149 | 4 | 158 | 94%NPV | |||
| 1: #anticonv | 1.138 | 0.000 | 53.123 | 68.348 | 2 | 5 | 7 | 71%PPV | |||
| 2: aEEG | 2.077 | 0.001 | 31.916 | 52.217 | 151 | 9 | 168 | ||||
| 99% Sp | 56% Se | 96% PA | |||||||||
| 2: Predicting all CP n = 160 excluding 17 dead and 1 survivor not scanned |
n = 22 All MRI, clinical and biochem. variables |
0:constant | −3.300 | 0.000 | 160 | 135 | 10 | 145 | 93%NPV | ||
| 1:WMxBGT | 0.915 | 0.000 | 70.255 | 85.480 | 3 | 12 | 15 | 80%PPV | |||
| 138 | 22 | 160 | |||||||||
| 98% Sp | 55% Se | 92% PA | |||||||||
|
n = 22 All MRI, except WMxBGT, and clinical and biochemical variables |
0:constant | −5.755 | 0.000 | 160 | 134 | 10 | 144 | 93%NPV | |||
| 1: TIS | 0.913 | 0.000 | 60.288 | 75.514 | 4 | 12 | 16 | 75%PPV | |||
| 138 | 22 | 160 | |||||||||
| 97% Sp | 55% Se | 91% | |||||||||
|
n = 22 Clinical and biochemical variables only |
0:constant | −6.439 | 0.000 | 160 | 135 | 14 | 149 | 91%NPV | |||
| 1: #anticonv | 0.789 | 0.000 | 103.287 | 118.513 | 3 | 8 | 11 | 73% PPV | |||
| 2:aEEG | 1.081 | 0.001 | 87.437 | 107.738 | 138 | 22 | 160 | ||||
| 98% Sp | 36% Se | 89% PA | |||||||||