Fig. 6.

Estimated median morphine plasma concentrations at steady-state for various hourly infusion rates, for birthweight=3500 g using clearance (L/h) = 0.765 as reported by Frymoyer [17]. A proposed therapeutic target plasma concentration is 10–100 µg/L (light blue bars). Periodically, infusion rates as high as 60 µg/kg/h were given in our cohort (medium blue bars).