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. 2021 Jan 5;4(1):4–17. doi: 10.1136/bmjnph-2020-000183

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Supervised beego alleviates thrombosis risk after water-only fasting and refeeding. (a) The Beego protocol used in the present study comprised seven complete water-only fasting days (wFD), associated with psychological induction and breath training, followed by seven refeeding days (rFD). Testing was performed at 07:00 to 09:00 a.m. of the following days: wFD 1, 4, 7 and rFD 7 as indicated. (b) Blood triacylglycerol (TG) test in TG normal (male=6, female=16) and high (male=4, female=3) subjects. (c) Blood total cholesterol (TC) test in TC normal (male=5, female=12) and TC high (male=5, female=7) subjects. (d) Low-density lipoprotein cholesterol (LDL-C) test in LDL-C normal (male=5, female=13) and high (male=5, female=6) subjects. (e) High-density lipoprotein cholesterol (HDL-C) in the normal (male=7, female=10) and low (male=4, female=1) subjects. (f) Bubble diagram of plasma proteomics analysis (label-free data-independent acquisition) for 10 subjects for each group (5 for male and female each, aged 30 to 60). Gene ontology enrichment analysis for three categories of proteins responsible for platelet-related thrombosis risk, with comparison between the testing days as indicated. Fold change is shown by the colour and q value for statistical significance is represented by the size of the dots. Data are means±SEM. *p<0.05; **p<0.01; ***p<0.001. *significant compared with the wFD1 immediately before the start of fasting.