Table 4.
The genotype and allele associations with overweight/obesity in Kazakhs and Russians and the frequencies of the genetic variation
| SNP (gene) | Genotype/allele | Kazakhs | Russians | Kazakhs | Russians | P value | ||
| OR (95% CI) | P value | OR (95% CI) | P value | n (%) | n (%) | |||
| rs1205 (CRP) | Genotype | |||||||
| CC | 1 | 1 | 25 (27.1) | 35 (50.7) | 0.020* | |||
| CT | 0.46 (0.17 to 1.26) | 0.132 | 0.67 (0.25 to 1.78) | 0.420 | 49 (53.3) | 30 (43.5) | ||
| TT | 1.02 (0.30 to 3.45) | 0.977 | 1.99 (0.19 to 21.23) | 0.565 | 18 (19.6) | 4 (5.8) | ||
| Allele | ||||||||
| C | 1 | 1 | 99 (53.8) | 100 (72.5) | 0.001* | |||
| T | 0.95 (0.52 to 1.74) | 0.861 | 0.93 (0.44 to 1.98) | 0.854 | 85 (46.2) | 38 (27.5) | ||
| rs5186 (AGTR1) | Genotype | |||||||
| AA | 1 | 1 | 60 (65.2) | 34 (49.3) | 0.096 | |||
| AC | 0.26 (0.09 to 0.78) | 0.016* | 0.51 (0.19 to 1.37) | 0.182 | 30 (32.6) | 31 (44.9) | ||
| CC | 1.31 (0.08 to 21.9) | 0.852 | Absent | 2 (2.2) | 4 (5.8) | |||
| Allele | ||||||||
| A | 1 | 1 | 150 (81.5) | 99 (71.7) | 0.038* | |||
| C | 0.42 (0.17 to 1.03) | 0.059 | 0.99 (0.47 to 2.10) | 0.987 | 34 (18.5) | 39 (28.3) | ||
| rs234706 (CBS) | Genotype | |||||||
| AA | 1 | 1 | 6 (6.6) | 16 (23.2) | 0.000* | |||
| AG | 0.128 (0.02 to 0.78) | 0.026* | 0.197 (0.05 to 0.78) | 0.020* | 59 (64.8) | 50 (72.5) | ||
| GG | 0.80 (0.12 to 5.20) | 0.815 | Absent | 26 (28.6) | 3 (4.3) | |||
| Allele | ||||||||
| A | 1 | 1 | 71 (39.1) | 82 (59.4) | 0.000* | |||
| G | 1.67 (0.88 to 3.18) | 0.115 | 0.72 (0.36 to 1.44) | 0.354 | 111 (60.9) | 56 (40.6) | ||
| rs602662 (FUT2) | Genotype | |||||||
| AA | 1 | 1 | 12 (13.1) | 17 (24.6) | 0.062 | |||
| AG | 0.51 (0.14 to 1.92) | 0.320 | 1.09 (0.31 to 3.81) | 0.892 | 36 (39.1) | 30 (43.5) | ||
| GG | 0.21 (0.05 to 0.81) | 0.023* | 0.31 (0.08 to 1.17) | 0.084 | 44 (47.8) | 22 (31.9) | ||
| Allele | ||||||||
| A | 1 | 1 | 60 (32.6) | 64 (46.4) | 0.012* | |||
| G | 0.42 (0.22 to 0.80) | 0.008* | 0.50 (0.25 to 0.99) | 0.046* | 124 (67.4) | 74 (53.6) | ||
| rs1799889 (PAI-1) | Genotype | |||||||
| AA | 1 | 1 | 21 (22.8) | 19 (27.5) | 0.714 | |||
| AG | 0.6 (0.21 to 1.68) | 0.332 | 0.27 (0.07 to 0.97) | 0.045* | 51 (55.4) | 34 (49.3) | ||
| GG | 0.28 (0.07 to 1.10) | 0.069 | 0.21 (0.05 to 0.91) | 0.037* | 20 (21.8) | 16 (23.2) | ||
| Allele | ||||||||
| A | 1 | 1 | 93 (50.5) | 72 (52.2) | 0.772 | |||
| G | 0.58 (0.31 to 1.07) | 0.081 | 0.47 (0.24 to 0.93) | 0.031* | 91 (49.5) | 66 (47.8) | ||
| rs1800871 (IL-10) | Genotype | |||||||
| AA | 1 | 1 | 20 (22.2) | 7 (10.4) | 0.018* | |||
| AG | 0.30 (0.09 to 0.93) | 0.038* | 0.17 (0.02 to 1.58) | 0.119 | 43 (47.8) | 26 (38.8) | ||
| GG | 0.69 (0.21 to 2.20) | 0.529 | 0.21 (0.02 to 1.95) | 0.170 | 27 (30) | 34 (50.8) | ||
| Allele | ||||||||
| A | 1 | 1 | 83 (46.1) | 40 (29.9) | 0.004* | |||
| G | 0.87 (0.47 to 1.61) | 0.657 | 0.71 (0.33 to 1.52) | 0.379 | 97 (53.9) | 94 (70.1) | ||
| rs1801131 (MTHFR) | Genotype | |||||||
| GG | 1 | 1 | 9 (9.9) | 13 (19.1) | 0.083 | |||
| GT | 0.33 (0.08 to 1.41) | 0.132 | 0.29 (0.07 to 1.21) | 0.089 | 45 (49.5) | 23 (33.8) | ||
| TT | 0.43 (0.09 to 1.89) | 0.267 | 0.74 (0.19 to 2.94) | 0.670 | 37 (40.6) | 32 (47.1) | ||
| Allele | ||||||||
| G | 1 | 1 | 63 (34.6) | 49 (36.0) | 0.794 | |||
| T | 0.85 (0.44 to 1.61) | 0.613 | 1.05 (0.52 to 2.13) | 0.891 | 119 (65.4) | 87 (64.0) | ||
| rs1801133 (MTHFR) | Genotype | |||||||
| AA | 1 | Absent | 9 (9.7) | 0 | 0.122 | |||
| AG | 0.33 (0.07 to 1.60) | 0.168 | 0.64 (0.24 to 1.72) | 0.375 | 29 (31.2) | 35 (51.5) | ||
| GG | 0.89 (0.22 to 3.71) | 0.882 | 1 | 55 (59.1) | 33 (48.5) | |||
| Allele | ||||||||
| A | Reference | Reference | 47 (25.3) | 42 (30.9) | 0.266 | |||
| G | 1.41 (0.69 to 2.88) | 0.346 | 0.81 (0.39 to 1.69) | 0.568 | 139 (74.7) | 94 (69.1) | ||
Genotypes GG (rs1801133), GG (rs234706) and CC (rs5186) were absent in Russian group. GG genotype was chosen as the reference group for rs1801133 in Russians.
*Statistically significant p values (<0.05).
SNP, single nucleotide polymorphism.