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. 2021 Jun 22;12:665951. doi: 10.3389/fphar.2021.665951

TABLE 1.

Univariate analysis of complications.

Characteristic Total DN P DPN P DA P DED P KE P
Duration of unadjusted hypoglycemic treatment <0.0001 <0.0001 <0.0001 <0.0001 0.0284
1 94 8(8.51%) 12(12.77%) 6(6.38%) 2(2.13%) 1(1.06%)
2 37 12(32.43%) 21(56.76%) 16(43.24%) 3(8.11%) 0(0%)
≥3 34 19(55.88%) 32(94.12%) 20(58.82%) 10(29.41%) 3(8.82%)
Gender 0.5902 0.5989 0.9407 0.5286 0.5110
Male 97 21
39(40.21%) 25(25.77%) 10(10.31%) 3(3.09%)
(21.65%)
Female 68 17(25.00%) 25(36.76%) 17(25.00%) 5(7.35%) 1(1.47%)
Age 0.1073 0.2169 0.3698 0.4278 0.0664
≤ 45 12 2(16.67%) 5(41.67%) 5(41.67%) 1(8.33%) 1(8.33%)
45–55 (included) 36 6(16.67%) 12(33.33%) 9(25.00%) 3(8.33%) 2(1.20%)
55–65 (included) 34 6(17.65%) 11(32.35%) 10(29.41%) 2(5.88%) 0(0%)
65–75 (included) 38 11(28.95%) 14(36.84%) 6(15.79%) 3(7.89%) 1(2.63%)
> 75 45 13(28.89%) 22(48.89%) 12(26.67%) 6(13.33%) 0(0%)
Duration of T2D <0.0001 0.0022 0.0015 0.0082 0.7701
1–2 (included) years 22 0(0%) 4(18.18%) 2(9.09%) 0(0%) 1(4.55%)
2–5 (included) years 22 3(13.64%) 5(22.73%) 2(9.09%) 1(4.55%) 0(0%)
5–10 (included) years 71 13(18.31%) 28(39.44%) 19(26.76%) 5(7.04%) 2(2.82%)
> 10 years 50 22(44.00%) 27(54.00%) 19(38.00%) 9(18.00%) 1(2.00%)
Hereditary history 0.5824 0.037 0.1291 0.0189 0.714
No 113 26(23.01%) 39(34.51%) 26(23.01%) 7(6.19%) 2(1.77%)
Yes 37 10(27.03%) 20(54.05%) 13(35.14%) 7(18.92%) 1(2.70%)

Data are number (%).

The duration of T2D and the duration of unadjusted hypoglycemic treatment were significant risk factors affecting DN, DPN, DA, and DED.

The genetic history of diabetes was a risk factor for DPN and DO.

DN, diabetic nephropathy; DPN, diabetic peripheral neuropathy; DA, diabetic angiopathy; DED, diabetic eye disease; KE, ketoacidosis.

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