TABLE 6.

Gastro-intestinal expression of sweet taste signaling molecules.

Organ	T1R2	T1R3	T2R	Gαgust	PLCβ2	TRPM5	GLUT/SGLT	KATP	Species	Source
Oeso- phagus	✓		✓		✓
			low		low				Human	Young et al., 2009
Stomach	✓	✓	✓	✓	✓	✓	✓	✓	Mouse	Hass et al., 2007; Kaske et al., 2007; Bezençon et al., 2008; Hass et al., 2010; Janssen et al., 2011; Widmayer et al., 2011; Sakata et al., 2012
Intestine	✓	✓	✓	✓		✓
				low					Human	Bezençon et al., 2007; Jang et al., 2007; Young et al., 2009
	✓	✓	✓	✓			✓		Mouse	Dyer et al., 2005; Margolskee et al., 2007; Janssen et al., 2011
							✓	✓	Rat	Kuhre et al., 2015
Colon		✓	✓	✓					Human	Taniguchi, 2004; Rozengurt et al., 2006
	✓	✓	✓
			low						Mouse	Bezençon et al., 2008; Reimann et al., 2008
						✓
						low			Rat	Jie et al., 2015
Pancreas		✓				✓	✓	✓	Human	Prawitt et al., 2003; Taniguchi, 2004
	✓	✓		✓		✓	✓	✓	Mouse	Prawitt et al., 2003; Nakagawa et al., 2009; Colsoul et al., 2010; Nakagawa et al., 2014
							✓	✓	Rat	Cook and Hales, 1984; Inagaki et al., 1995; Vos et al., 1995

Methods included: PCR (Prawitt et al., 2003; Dyer et al., 2005; Rozengurt et al., 2006; Margolskee et al., 2007; Bezençon et al., 2008; Nakagawa et al., 2009; Young et al., 2009; Widmayer et al., 2011; Sakata et al., 2012), in situ hybridization (Hass et al., 2007; Margolskee et al., 2007), immunohistochemistry (Taniguchi, 2004; Rozengurt et al., 2006; Hass et al., 2007; Jang et al., 2007; Kaske et al., 2007; Margolskee et al., 2007; Bezençon et al., 2008; Colsoul et al., 2010; Janssen et al., 2011; Widmayer et al., 2011), biochemical measurement (Kuhre et al., 2015), or transcriptome analysis (Jie et al., 2015).