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. 2021 Jun 22;9:672847. doi: 10.3389/fcell.2021.672847

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Copyright © 2021 Li, Liao, Luo, Song, Wang, Feng, Ou, Wu, Zhang, Gao, Yin and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of AIM2 retards IDD progression in vivo. (A) Histological staining, including hematoxylin-eosin (HE), safranin O (S-O), and Sirius red (S-R) staining, showed the morphology of rat disc tissues. The IDD, si-AIM2, and si-scr group were conducted with needle puncture. (B) Histological grades to evaluate the degree of disc degeneration in different group. (C,D) Immunochemistry results of γ-H2AX in rat dis tissues (C) and quantification of cγ-H2AX-positive cell rate (D). Data were presented as the means ± SD, n = 6. **P < 0.01, ***P < 0.001 vs. control group; ^##P < 0.01 vs. IDD group.