Table 3.

List of metabolic pathways identified in dog saliva after 30 days of Ascophyllum nodosum administration.

No.	Pathway Name	Total	Hits (all)	Hits (sig.)	p-value	Gamma P
1	Selenoamino acid metabolism	35	6	3	0.067	0.0,489
2	Tyrosine metabolism	160	28	6	0.350	0.068
3	Fatty acid metabolism	63	19	4	0.421	0.081
4	Drug metabolism - other enzymes	31	6	2	0.277	0.084
5	Vitamin E metabolism	54	21	4	0.504	0.091
6	Fatty acid activation	74	35	6	0.580	0.094
7	Porphyrin metabolism	43	15	3	0.494	0.097
8	Methionine and cysteine metabolism	94	9	2	0.478	0.110
9	Purine metabolism	80	17	3	0.584	0.110
10	Squalene and cholesterol biosynthesis	55	27	4	0.714	0.125
11	Pyrimidine metabolism	70	11	2	0.592	0.128
12	Urea cycle/amino group metabolism	85	12	2	0.641	0.136
13	Aspartate and asparagine metabolism	114	12	2	0.641	0.136
14	Vitamin A (retinol) metabolism	67	29	4	0.767	0.138
15	Linoleate metabolism	46	23	3	0.789	0.152
16	Drug metabolism - cytochrome P450	53	15	2	0.762	0.163
17	Xenobiotics metabolism	110	15	2	0.762	0.163
18	De novo fatty acid biosynthesis	106	34	4	0.867	0.170
19	Glycosphingolipid metabolism	67	17	2	0.822	0.181
20	Carnitine shuttle	72	21	2	0.902	0.215
21	Bile acid biosynthesis	82	23	2	0.929	0.232
22	Androgen and estrogen biosynthesis and metabolism	95	45	4	0.968	0.243
23	Glycerophospholipid metabolism	156	29	2	0.973	0.281
24	D4 & E4-neuroprostane formation	37	32	2	0.984	0.305
25	Leukotriene metabolism	92	44	3	0.989	0.305
26	C21-steroid hormone biosynthesis and metabolism	112	60	4	0.996	0.347
27	Prostaglandin formation from arachidonate	78	50	3	0.996	0.347