Table 1.

KEGG pathway and GO enrichment analysis of differentially expressed RBPs.

	GO term	P-value	FDR
Up-regulated RBPs	Gene silencing	1.53E-13	1.30E-10
	Posttranscriptional regulation of gene expression	4.95E-12	2.11E-9
	Regulation of gene expression, epigenetic	6.75E-11	1.91E-8
	DNA modification	1.08E-10	2.30E-8
	RNA catabolic process	1.66E-9	2.82E-7
	Regulation of cellular amide metabolic process	6.50E-9	9.21E-7
	Cellular process involved in reproduction in Multicellular organism	2.41E-8	2.64E-7
	Methylation	2.48E-8	2.64E-7
	dsRNA processing	6.70E-7	6.33E-5
	RNA modification	9.50E-7	8.08E-5
	Ribonucleoprotein granule	9.13E-10	1.57E-7
	Catalytic activity, acting on RNA	9.88E-15	2.79E-12
	mRNA binding	1.35E-9	1.91E-7
	Translation regulator activity	1.11E-7	1.04E-5
	Nucleotidyltransferase activity	6.98E-7	4.92E-5
	Pre-mRNA binding	8.30E-6	4.68E-5
	Double-stranded RNA binding	1.21E-5	5.67E-4
	Nuclease activity	1.51E-5	6.09E-4
	Ribonucleoprotein complex binding	1.53E-4	0.005
	Lipopolysaccharide binding	3.00E-4	0.009
	Regulatory RNA binding	4.18E-4	0.012
	MicroRNAs in cancer	5.45E-5	0.018
Down-regulated RBPs	mRNA processing	<0.001	<0.001
	Regulation of mRNA metabolic process	1.36E-13	4.64E-11
	Posttranscriptional regulation of gene expression	1.64E-13	4.64E-11
	Regulation of cellular amide metabolic process	1.26E-12	2.67E-10
	RNA splicing	5.92E-11	1.01E-8
	Cytoplasmic translation	6.22E-7	8.81E-5
	RNA catabolic process	1.79E-6	2.17E-4
	Response to oxygen levels	1.28E-4	0.014
	Epithelial cell apoptotic process	3.42E-4	0.030
	Response to ischemia	3.53E-4	0.030
	Ribonucleoprotein granule	5.14E-9	8.84E-7
	mRNA binding	<0.001	<0.001
	AU-rich element binding	5.03E-12	7.09E-10
	Translation factor activity, RNA binding	6.41E-10	6.03E-8
	Translation regulator activity	5.69E-8	4.01E-6
	Single-stranded RNA binding	6.34E-7	3.58E-5
	snRNA binding	3.55E-4	0.017
	Ribonucleoprotein complex binding	0.001	0.045
	Progesterone-mediated oocyte maturation	5.19E-5	0.017
	Oocyte meiosis	1.25E-4	0.020