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. 2021 Jun 22;9:684643. doi: 10.3389/fcell.2021.684643

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Copyright © 2021 Wu, Zhang, Wei, Feng, Hu, Deng, Liu, Luan, Ruan, Liu, Liu, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and distribution of differentially expressed URGs in ccRCC. (A) The differential expression of 204 ubiquitin related genes (URGs) in ccRCC tissue samples (n = 539) compared with normal renal samples (n = 72) is shown in the volcano plot. The red plot represented up-regulated URGs, the green plot represented down-regulated URGs; (B) the differential expression of 204 URGs in ccRCC tissue samples (n = 539) compared with normal renal samples (n = 72) is shown in the heatmap (the statistical method was multiple hypothesis testing).