Table 1.
Antiviral activities of compounds 1 and 2 against PEDV and FIPV.
| Compound | Name | PEDV | FIPV | |||||
|---|---|---|---|---|---|---|---|---|
| IC50
a
(µmol/L) |
CC50b (µmol/L) | EC50c (µmol/L) | SId values | CC50
(µmol/L) |
EC50
(µmol/L) |
SI values | ||
| 1 | 3-(aminocarbonyl)-1-phenylpyridinium | 0.1877 | 73.8 | 28.63 | 2.58 | 60.48 | 59.66 | 1.01 |
| 2 | 2,3-dichloronaphthoquinone | 6.765 | 21.79 | 38.45 | 0.56 | 36.7 | 46.03 | 0.80 |
a50% inhibitory concentration against PEDV 3CLpro;
b50% cytotoxic concentration in subcultured cells;
c50% effective concentration of test compound in inhibiting viral replication;
dselectivity index (SI = CC50/EC50). The IC50, CC50 and EC50 values were determined using GraphPad Prism 7