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. 2021 Jun 22;12:662020. doi: 10.3389/fphar.2021.662020

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Copyright © 2021 Marquez-Exposito, Tejedor-Santamaria, Santos-Sanchez, Valentijn, Cantero-Navarro, Rayego-Mateos, Rodrigues-Diez, Tejera-Muñoz, Marchant, Sanz, Ortiz, Goldschmeding and Ruiz-Ortega.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ferroptosis death pathway is significantly increased in FA-induced AKI in old vs. young mice. Folic Acid (FA; 125 mg/kg) was injected in 3-months-old (Young) and 1-year-old (Old) C57BL/6 and kidneys were studied after 48 h (A, B) 4-Hidroxynonenal (HNE) immunohistochemistry was performed. (A) Representative pictures from each group and (B) the quantification of stained area per total area was performed. (C) Renal gene expression levels of Gpx4 were studied by qRT-PCR. Scale bars = 100 μm. Data are expressed as mean ± SD of n = 6–9 animals per group. *p < 0,05 vs. Young mice control. The non-parametric Kruskal-Wallis statistical test was performed.