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. 2021 Jun 22;12:698436. doi: 10.3389/fmicb.2021.698436

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Copyright © 2021 Wang, Yang, Bao, Li, Yin, Wu, Chen, Tang, Li and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparisons of yield of the main bioactive compounds and growth of C. militaris and its sre1n-overexpressed transformants after 15 days’ fermentation. (A) Content of mycelial adenosine and cordycepin. (B) Content of extracellular adenosine and cordycepin in fermentation broth. (C) Dry weight of mycelial biomass of C. militaris and its tranformants growing in SDB for 15 days. (D) Crude mycelial polysaccharides. (E) Total crude mycelial polysaccharides in 50-mL fermentation broth. (F) Crude exo-polysaccharide in fermentation broth. WT: CM01; CK: transformation control; Sre1N1-3: randomly selected sre1n-overexpressed transformants. Error bars show standard deviation of three replicates. Significant differences between CM01 and transformants (Student’s t-test): *P < 0.05, **P < 0.01, ***P < 0.001.