Figure 3.

Mediators of chronic kidney disease.³⁶ Various inflammatory mediators are involved in the complex processes leading to the loss of kidney function. Adapted with permission from Elsevier. Originally published in Eur J Pharmacol. Vol 820. Lv W et al. Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets. Pages 65 to 76. Copyright 2018, Elsevier. ECM, extracellular matrix; EMT, epithelial-mesenchymal transdifferentiation; GFR, glomerular filtration rate; ROS, reactive oxygen species; TNF, tumor necrosis factor; TGF-β, transforming growth factor beta; TWEAK, TNF-like weak inducer of apoptosis.