Table 2.

Comparison of renal angina fulfillment to initial serum creatinine above baseline on day 1 of pediatric septic shock

Characteristic	RAI+	SCr>Baseline	Comparison RAI+ to SCr>Baseline
N (%)	207 (55)	220 (58)	—
Male	109 (53)	112 (51)	P = 0.79
Age, years	4.9 [1.2 to 10.4]	6.3 [1.6 to 12.3]	P = 0.19
History of transplant	34 (16)	30 (14)	P = 0.50
Severity of illness
PRISM-III	12 [8 to 18]	12 [8 to 18]	P = 0.52
PERSEVERE-II	0.019 [0.007 to 0.189]	0.019 [0.007 to 0.189]	P = 0.84
RAI	20 [10 to 40]	10 [6 to 24]	P < 0.001
D3 SA-AKI
All stage	87 (42)	85 (39)	RR 1.1 (0.86 to 1.4, P = 0.54)
Severe	64 (31)	58 (26)	RR 1.2 (0.87 to 1.6, P = 0.35)
D3 Severe SA-AKI Prediction
AUROCa	0.90 (0.86 to 0.93)	0.85 (0.80 to 0.91)	P = 0.11
Sensitivity, %	98 (91 to 99)	89 (78 to 95)	—
Specificity, %	54 (49 to 60)	48 (43 to 54)	—
PPV, %	31 (25 to 38)	26 (21 to 33)	—
NPV, %	99 (96 to 99)	92 (91 to 98)	—
Positive likelihood ratio	2.2 (1.9 to 2.4)	1.7 (1.5 to 2.0)	—
Negative likelihood ratio	0.03 (0.004 to 0.20)	0.22 (0.11 to 0.45)	—
RRT use	37 (18)	32 (15)	RR 1.2 (0.8 to 1.9, P = 0.42)
PICU LOS, days	8 [5 to 19]	7 [3 to 13]	P = 0.005
Mortality	35 (17)	34 (16)	RR 1.1 (0.71 to 1.69, P = 0.78)

AUROC, area under the receiver operating curve; D, day; IQR, interquartile range; LOS, length of stay; NPV, negative predictive value; PERSEVERE-II, updated Pediatric Sepsis Biomarker Risk Model mortality probability; PICU, pediatric intensive care unit; PPV, positive predictive value; PRISM-III, Pediatric Risk of Mortality Score; RAI+, renal angina index ≥ 8; RRT, renal replacement therapy; SA-AKI, sepsis-associated acute kidney injury; SCr > baseline, serum creatinine above baseline

Values are n (%) unless otherwise noted. All continuous variables reported as median [IQR].

^aAUROC reported for RAI and SCr/Baseline as continuous variables