Table 3.
Multivariable logistic regression testing for an association between renal angina fulfillment (RAI+), serum creatinine above baseline (SCr > baseline), age, and severity of illness with sepsis-associated acute kidney injury outcomes
| Outcome | Variable | Adjusted OR | 95% CI | P |
|---|---|---|---|---|
| D3 severe SA-AKI | PRISM-III | 1.04 | 0.99 to 1.09 | 0.086 |
| PERSEVERE-IIa | 1.46 | 1.18 to 1.80 | <0.001 | |
| Age, years | 1.03 | 0.99 to 1.07 | 0.19 | |
| RAI+ | 50.9 | 6.7 to 387 | <0.001 | |
| SCr > baseline | 2.41 | 0.97 to 5.97 | 0.057 | |
| RRT use | PRISM-III | 1.05 | 0.99 to 1.10 | 0.057 |
| PERSEVERE-IIa | 1.66 | 1.31 to 2.11 | <0.001 | |
| Age, years | 1.03 | 0.99 to 1.09 | 0.18 | |
| RAI+ | 30.9 | 3.82 to 250 | 0.001 | |
| SCr > baseline | 1.09 | 0.39 to 3.07 | 0.88 | |
| 28-day mortality | PRISM-III | 1.03 | 0.98 to 1.08 | 0.22 |
| PERSEVERE-IIa | 1.96 | 1.56 to 2.46 | <0.001 | |
| Age, years | 1.03 | 0.98 to 1.08 | 0.30 | |
| RAI+ | 3.40 | 1.22 to 9.45 | 0.019 | |
| SCr > baseline | 1.40 | 0.53 to 3.68 | 0.50 |
CI, confidence interval; D, days; OR, odds ratio; PERSEVERE-II, updated Pediatric Sepsis Biomarker Risk Model mortality probability; PRISM-III, Pediatric Risk of Mortality Score; RAI, renal angina index; RRT, renal replacement therapy; SCr, serum creatinine.
a
The raw PERSEVERE-II mortality probability was transformed by a factor of 10 for the logistic regression analyses.