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. 2021 Jul 1;22(2):630. doi: 10.3892/ol.2021.12891

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Proteomic analysis identified deferentially expressed proteins between HSP60-KD cells and control cells. (A) A total of 575 proteins and 53 proteins were found to be significantly upregulated and downregulated, respectively, in HSP60-KD HCT116 cells by proteomic analysis. (B) Ingenuity Pathway Analysis indicated that 11 cancer-associated pathways were significantly inhibited in HSP60-KD HCT116 cells, and ‘oxidative phosphorylation’ was the most inhibited pathway based on z-scores. (C) Downstream functional analysis by Ingenuity Pathway Analysis identified significantly activated (z-score >2; P<0.05) and inhibited (z-score <-2; P<0.05) functions in HSP60-KD HCT116 cells. HSP60, heat shock protein 60; KD, knockdown.