Table 1.
Proposed interactions between STAC and Cav channels
| Protein | Domain | Residue range | Binding partner | Functional significance | Expression system | Reference |
|---|---|---|---|---|---|---|
| STAC | C1 domain | 93–150 | Cav1.2 | Stable interaction, CDI | Dysgenic myotubes, tsA201 cells | (69) |
| U-motif | 174–191 | Cav1.2, Cav1.3 | CDI | HEK293 cells | (77) | |
| Linker region | 171–289 | Cav1.2 | CDI | tsA201 cells | (76) | |
| Tandem SH3 | 245–364 | Cav1.1 II-III loop | ECC | Purified protein | (56) | |
| Cav1.1 | II-III loop | 747–760 (minimal peptide) | STACa SH3 domains | ECC | Purified protein | (56) |
| II-III loop | 745–765 | STACa SH3 domains | ECC | STAC3-null myotubes, tsA201 cells | (59) | |
| Cav1.2 | Proximal CTD (IQ) | 1689–1716 | STACa | CDI | Dysgenic myotubes | (78) |
| Proximal CTD | 1526–1858 | STACa | CDI | tsA201 cells | (76) | |
| Cav1.3 | Proximal CTD (EF + pre-IQ) | 1463–1593 | STACa | CDI | HEK293 cells | (77) |
| Cav3.2 | Distal NTD | 51–100 | STAC1 | Trafficking | tsA201 cells | (67) |
Abbreviations: CDI, calcium-dependent inactivation; ECC, excitation–contraction coupling.
All residues numbering is for the human isoform and the STAC numbering corresponds to STAC3.
a
The interaction is shown for all isoforms.