Table 1.
Demographic characteristics, pulmonary function test results, hemodynamics, and echocardiography parameters of patients.
| All patients | PDW ≥ 16.1% | PDW < 16.1% | ||
|---|---|---|---|---|
| N = 67 | N = 22 | N = 45 | P a | |
| Age (years) | 58.0 ± 12.9 | 58.1 ± 13.2 | 58.0 ± 12.9 | 0.963 |
| Male (n, %) | 38 (56.7) | 13 (81.3) | 25 (49.0) | 0.189 |
| BSA (m2) | 1.58 ± 0.20 | 1.58 ± 0.20 | 1.59 ± 0.20 | 0.989 |
| COPD | 14 (63.6) | 12 (75.0) | 23 (51.1) | 0.337 |
| Bronchiectasis | 12 (16.1.9) | 4 (18.2) | 8 (17.8) | 0.968 |
| ILD | 6 (9.0) | 2 (9.1) | 4 (8.9) | 0.978 |
| Others | 12 (20.9) | 2 (9.1) | 10 (22.2) | 0.191 |
| Pulmonary function test | ||||
| FEV1% predicted | 32.4 (24.0, 44.0) | 35.0 (25.8, 43.7) | 31.5 (24.0, 47.9) | 0.828 |
| FEV1/FVC % predicted | 47.4 (42.8, 56.1) | 43.3 (36.3, 51.5) | 48.8 (43.7, 59.7) | 0.063 |
| RV % predicted | 204.1 ± 80.4 | 230.5 ± 99.3 | 197.1 ± 74.8 | 0.272 |
| TLC % predicted | 113.6 ± 29.3 | 126.6 ± 31.0 | 110.1 ± 28.3 | 0.136 |
| DLCO % predicted | 40.9 (27.9, 56.2) | 26.0 (23.9, 48.7) | 42.0 (30.0, 58.5) | 0.090 |
| Hemodynamics | ||||
| mPAP (mmHg) | 46.0 (42.0, 55.0) | 49.0 (42.0, 58.3) | 46.0 (41.5, 54.0) | 0.411 |
| PAWP (mmHg) | 9.8 ± 4.0 | 10.0 ± 3.9 | 9.7 ± 4.1 | 0.818 |
| CO (L/min) | 4.6 (4.0, 5.7) | 4.2 (3.9, 5.4) | 4.7 (4.3, 6.2) | 0.063 |
| CI (L/min/m2) | 3.1 (2.6, 3.7) | 2.8 (2.5, 3.6) | 3.2 (2.7, 3.7) | 0.159 |
| PVR, Wood units | 8.0 (6.3, 10.2) | 9.1 (6.5, 10.7) | 7.5 (5.9, 9.5) | 0.149 |
| Echocardiography | ||||
| LVEF (%) | 70.9 ± 9.0 | 70.6 ± 9.9 | 70.8 ± 8.8 | 0.923 |
| RATD (cm) | 4.8 (4.3, 5.5) | 5.3 (4.6, 5.9) | 4.7 (4.3, 5.5) | 0.112 |
| RALD (cm) | 5.2 (4.3, 5.9) | 5.5 (5.0, 6.2) | 5.1 (4.3, 5.9) | 0.131 |
| RVEDTD (cm) | 4.3 (3.8, 5.0) | 4.4 (4.0, 5.3) | 4.2 (3.8, 4.9) | 0.319 |
| RVEDLD (cm) | 6.6 ± 0.9 | 6.8 ± 0.6 | 6.5 ± 1.0 | 0.197 |
| PASP (mmHg) | 76.2 ± 22.6 | 80.6 ± 26.5 | 74.0 ± 20.4 | 0.265 |
| TAPSE (cm) | 1.7 (1.5, 1.9) | 1.7 (1.4, 1.9) | 1.8 (1.6, 2.0) | 0.220 |
| ENDSEI | 1.3 (1.0, 1.5) | 1.4 (1.1, 1.8) | 1.2 (1.0, 1.4) | 0.079 |
Values are mean ± standard deviation, median (interquartile interval) or n (%). CO: cardiac output; COPD: chronic obstructive pulmonary diseases; ILD: interstitial lung disease; mPAP: mean pulmonary artery pressure; RAP: right atrial pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; RV: residual volume; TLC: total lung capacity; DLCO: diffusion capacity for carbon monoxide of the lung; PDW: platelet distribution width. Others included pulmonary lobectomy, chest deformity, lung destruction due to tuberculosis, pneumoconiosis, combined pulmonary fibrosis and emphysema. RVEDTD: right ventricular end-diastolic transverse dimension; RVEDLD: right ventricular end-diastolic longitudinal dimension; RATD: right atrial transverse dimension; RALD: right atrial longitudinal dimension; PASP: pulmonary arterial systolic pressure; ENDSEI: end-systolic stage eccentricity index; TAPSE: tricuspid annular plane systolic excursion; LVEF: left ventricular ejection fraction.
aWhen the Bonferroni method was employed for correcting for the significance level for 25 comparisons made in this study, the adjusted significant level was 0.002.