Table 2.
Cox proportional hazards regression analysis for all-cause death in patients with severe CLD-PH.
| Univariate analysis |
Multivariate-adjusted analysis |
|||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender | 0.696 (0.381–1.271) | 0.239 | ||
| COPD | 2.357 (1.258–4.416) | 0.007 | ||
| Red blood cell (×1012/L) | 1.187 (0.829–1.689) | 0.350 | ||
| White blood cell (×109/L) | 0.932 (0.840–1.033) | 0.179 | ||
| Platelet (×109/L) | 0.996 (0.991–1.001) | 0.089 | ||
| Red blood cell distribution Width (%) | 1.027 (0.979–1.076) | 0.273 | ||
| PDW (%) | 1.245 (1.121–1.384) | <0.001 | 1.245 (1.117–1.386) | <0.001 |
| Platelet crit (%) | 0.006 (0.000–0.881) | 0.044 | ||
| Mean platelet volume (fl) | 0.992 (0.934–1.053) | 0.786 | ||
| FEV1/FVC % predicted | 0.973 (0.935–1.012) | 0.717 | ||
| DLCO % predicted | 0.999 (0.982–1.016) | 0.892 | ||
| mPAP (mmHg) | 1.016 (0.986–1.047) | 0.239 | ||
| PVR (Wood units) | 1.065 (0.994–1.141) | 0.074 | ||
| CI (L/min/m2) | 0.659 (0.454–0.958) | 0.029 | 0.667 (0.455–0.978) | 0.038 |
| RATD (cm) | 1.102 (0.837–1.405) | 0.491 | ||
HR: hazard ratio; CI: confidence interval; mPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; CI: cardiac index; CLD-PH: pulmonary hypertension due to chronic lung diseases; PDW: platelet distribution width; PCT: platelet crit; MPV: mean platelet volume; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; DLCO: diffusion capacity for carbon monoxide of the lung; RATD: right atrial transverse dimension; COPD: chronic obstructive pulmonary diseases.