Table 2.
Multivariable-adjusted mean percent difference and 95% CI for total and regional fat and lean body mass by hysterectomy and oophorectomy status and age at DXA scan*
| DXA Measure | Subgroup | Age <45 y (n=1,365) |
Age ≥45 y (n=2,844) |
||||
|---|---|---|---|---|---|---|---|
| n | β (95% CI) | P value | n | β (95% CI) | P value | ||
| Total Fat Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | 1.33 (0.00, 2.66) | 0.051 | 377 | 0.76 (0.02, 1.51) | 0.046 | |
| Hysterectomy & oophorectomy | 70 | 3.25 (1.03, 5.54) | 0.005 | 482 | 1.29 (0.56, 2.01) | <0.001 | |
| Total Lean Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | −1.22 (−2.47, 0.03) | 0.055 | 377 | −0.73 (−1.42, −0.02) | 0.041 | |
| Hysterectomy & oophorectomy | 70 | −2.86 (−5.00, −1.07) | 0.009 | 482 | −1.20 (−1.87, −0.53) | <0.001 | |
| Trunk Fat Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | 1.76 (−0.04, 3.56) | 0.056 | 377 | 1.29 (0.23, 2.36) | 0.017 | |
| Hysterectomy & oophorectomy | 70 | 4.79 (2.08, 7.50) | <0.001 | 482 | 1.72 (0.78, 2.67) | <0.001 | |
| Trunk Lean Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | −1.70 (−3.46, 0.06) | 0.061 | 377 | −1.26 (−2.30, −0.20) | 0.016 | |
| Hysterectomy & oophorectomy | 70 | −4.56 (−7.20, −1.92) | <0.001 | 482 | −1.67 (−2.60, −0.74) | <0.001 | |
| Arms Fat Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | 1.33 (−0.41, 3.03) | 0.135 | 377 | 0.58 (−0.40, 1.56) | 0.242 | |
| Hysterectomy & oophorectomy | 70 | 3.56 (0.75, 6.37) | 0.013 | 482 | 1.13 (0.20, 2.14) | 0.029 | |
| Arms Lean Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | −1.11 (−2.76, 0.53) | 0.184 | 377 | −0.52 (−1.43, 0.39) | 0.259 | |
| Hysterectomy & oophorectomy | 70 | −3.07 (−5.72, −0.43) | 0.023 | 482 | −1.04 (−1.99, −0.09) | 0.033 | |
| Legs Fat Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | 0.95 (−0.53, 2.43) | 0.208 | 377 | 0.14 (−0.54, 0.82) | 0.691 | |
| Hysterectomy & oophorectomy | 70 | 1.37 (−0.97, 3.70) | 0.252 | 482 | 0.87 (0.20, 1.52) | 0.011 | |
| Legs Lean Mass | No surgery | 1,227 | Reference | 1,985 | Reference | ||
| Hysterectomy | 68 | −0.85 (−2.25, 0.54) | 0.231 | 377 | −0.16 (−0.81, 0.50) | 0.639 | |
| Hysterectomy & oophorectomy | 70 | −1.07 (−3.28, 1.14) | 0.343 | 482 | −0.80 (−1.43, −0.18) | 0.012 | |
Abbreviations: DXA, dual-energy x-ray absorptiometry; CI, confidence interval.
*
Median (interquartile range) time since hysterectomy and oophorectomy, <45 years: 6 years (2–10 years) and ≥45 years: 16 years (7–23 years); Median time since hysterectomy, <45 years: 5 years (2–11 years) and ≥45 years: 19 years (12–26 years). Adjusted for age, race, smoking, alcohol use, physical activity, BMI at age 25, parity, oral contraceptive use, and post-surgery estrogen replacement therapy use.