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. 2021 Jul 5;18:150. doi: 10.1186/s12974-021-02198-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Increased expressions of IL-33 and ST2 in the RN of SNI rats. A Mononeuropathic pain induced by SNI (n = 6 per group, F = 198.886, P < 0.001). B Western blotting showed that red nucleus IL-33 was increased at 3 days, peaked at 1 week and returned to normal level at 2 weeks post-SNI (n = 6 per group, F = 9.435, P < 0.001). C Immunohistochemistry indicated that red nucleus IL-33 was upregulated at 3 days, peaked at 1 week and returned to normal level at 2 weeks post-SNI (n = 4 per group, F = 50.817, P < 0.001). D Western blotting showed that red nucleus ST2 was increased at 3 days, peaked at 1 week, and still remained at a high level at 3 weeks post-SNI (n = 6 per group, F = 7.693, P < 0.001). E, F Immunohistochemistry (n = 4 per group) indicated that red nucleus ST2 was upregulated at 3 days, peaked at 1 week, and still kept at a high level at 3 weeks post-SNI (n = 4 per group, F = 39.934, P < 0.001). *P < 0.05 and ***P < 0.001. Scale bars = 50 μm