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. 2021 May 21;53:101260. doi: 10.1016/j.molmet.2021.101260

Figure 2.

Figure 2

Male sex hormones regulate the density of peri-islet sensory innervation in adulthood. The pancreas from six-week-old male and female C57BL/6J mice were co-stained with insulin (red) and CGRP (green) antibodies. A. Representative confocal images of pancreatic islets from male (upper) and female (lower) mice. B. Quantification of the peri-islet CGRP+ axon terminals in A. The pancreas from six-month-old control male, orchidectomized male and control female C57BL/6J mice were co-stained as describe above. Data represent mean ± SEM. Student's t-test: ∗p ≤ 0.05 (n = 5). C. Representative confocal images of pancreatic islets from male (to panel), orchidectomized male (middle panel) and female (bottom panel) mice. D. Quantification of the peri-islet CGRP+ axon terminals in C. Data represent mean ± SEM. One-way ANOVA with Tukey's multiple-comparisons test: ∗p < 0.01 and ∗∗p < 0.01 (n = 6) vs male group.