Table 1.
Description of PET studies conducted using the radioligands [11C]AZD9272 or [11C]L-deprenyl-D2.
| Radioligand | NHP # | NHP body weight (kg) | Anaesthesia | Sevoflurane concentration (vol%) | Injected radioactivity (MBq) |
|---|---|---|---|---|---|
| [11C]AZD9272 | 1, 2, 3 | 7.8, 7.2, 7.0 | Ketamine/xylazine | – | 131–206 |
| 1, 2, 3 | 7.6, 8.6, 6.9 | Sevoflurane | 2.5 and 2.9∗ | 112–212 | |
| [11C]L-Deprenyl-D2 | 4, 5, 6 | 7.0, 9.3, 6.8 | Ketamine/xylazine | – | 156–167 |
| 4, 5, 6 | 7.0, 9.3, 6.8 | Sevoflurane | 3.4–3.8 | 153–163 |
∗Data not available for NHP#1. NHP, non-human primate; PET, positron emission tomography.