Table 2.
Regional estimates of total volume of distribution (VT, ml cm−3) for [11C]AZD9272 and λk3 (ml cm−3 min−1) for [11C]L-deprenyl-D2 in non-human primates anaesthetised with ketamine/xylazine or sevoflurane. Values are presented as mean (range; n=3).
| Brain region |
VT [11C]AZD9272 |
λk3 [11C]L-Deprenyl-D2 |
||
|---|---|---|---|---|
| Ketamine/xylazine | Sevoflurane | Ketamine/xylazine | Sevoflurane | |
| Caudate nucleus | 17 (13–20) | 4.8 (4.1–5.7) | 0.40 (0.39–0.42) | 0.09 (0.08–0.11) |
| Cerebellum | 9.3 (8.0–10) | 3.1 (2.6–4.0) | 0.22 (0.20–0.23) | 0.06 (0.05–0.06) |
| Prefrontal cortex | 9.2 (8.5–9.7) | 3.5 (2.8–4.5) | 0.25 (0.24–0.26) | 0.06 (0.06–0.07) |
| Putamen | 11 (9.7–12) | 4.2 (3.7–5.0) | 0.28 (0.27–0.29) | 0.07 (0.06–0.08) |
| Thalamus | 15 (13–17) | 4.4 (3.8–5.3) | 0.34 (0.33–0.35) | 0.07 (0.07–0.08) |
| Ventral midbrain | 13 (11–14) | 3.9 (3.5–4.5) | 0.26 (0.24–0.27) | 0.05 (0.05–0.06) |