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. 2021 Jul 6;11:17. doi: 10.1186/s13395-021-00274-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Amiloride inhibited tumor-derived exosome release both in vitro and in vivo. a Gastrocnemius weights of the NOR and NOR-AM mice in the CT26/LLC models (n = 6). b Plasma exosome densities of the NOR and NOR-AM mice in the CT26/LLC models (n = 6). c Body weights of the NOR and NOR-AM mice in the CT26/LLC models (n = 6). d Exosome densities in culture media of the CT26, CT26-AM, LLC, and LLC-AM cells (n = 4). Cells were treated by amiloride at 10 μM for 6 h. e Plasma exosome densities of the NOR, CAC, AM, and KD mice in the CT26 model (n = 8). f Plasma exosome densities of the NOR, CAC, AM, and KD mice in the LLC model (n = 8). Statistical significances: p > 0.05, NS; p < 0.05, *; p < 0.01, **; p < 0.001, ***. NOR, C57BL/6 or BALB/c normal control mice; NOR-AM, amiloride-treated NOR mice; CAC, CT26/LLC cachexia mice; AM, amiloride-treated CT26/LLC mice; KD, mice inoculated with Rab27-knockdown CT26/LLC cells; CT26-AM, amiloride-treated CT26 cells; LLC-AM, amiloride-treated LLC cells